Manganese

Manganese is a mineral that must be obtained in the diet and is required in trace amounts.

Manganese is a cofactor in several enzymes, many of which are particularly essential in the detoxification of superoxide free radicals. One such enzyme is manganese superoxide dismutase, which is the principal antioxidant in mitochondria. Other manganese-containing enzymes play important roles in the metabolism of carbohydrates, amino acids, and cholesterol. Glutamine synthetase, is a manganese-containing enzyme in the brain that converts the amino acid glutamate (itself an excitotoxic neurotransmitter) to glutamine.

Manganese is required in trace amounts and deficiency in humans is not well described.

Manganese is a remedy for sprains, arthritis, and other connective tissue condition involving inflammation due to its role in manganese superoxide dismutase. Manganese supplements have also been used for seizures and osteoporosis, and to promote wound healing.

Side effects are rare at usual doses used in supplementation. Manganese is considered to be safe at doses under 11 mg a day in adults.

Laboratory testing is available, but is generally used to detect environmental toxicity.