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Mast Cell Activation Syndrome: By Richard G. Boles, M.D.; 9/20/24

Mast cell activation syndrome (MCAS) is a common yet under-recognized condition. In MCAS, a person has frequent allergy reactions (e.g., hives, wheezing, nausea) to multiple environmental substances, including foods, medications, and scents. Next week (9/27), Richard G. Boles, M.D. will be presenting his research findings [...]

Clinical Insights in Cyclic Vomiting Syndrome Based on Genetic Findings

Summary on Dr. Boles’ Cyclic Vomiting Article: Clinical Insights in Cyclic Vomiting Syndrome Based on Genetic Findings Published in March 2024 In May 2023, Dr. Richard G. Boles and his research group published a scientific paper on cyclic vomiting syndrome (CVS) in Frontiers of Neurology [...]

AUTISM IS GENETIC (A DEEP DIVE); AUTISM IS TREATABLE

Autism is Genetic; Autism is Treatable; These Statements Are NOT in Conflict On 18 January, 2024, Dr. Richard G. Boles and his research group published a major scientific paper in the prestigious International Journal of Molecular Sciences entitled: “Reanalysis of trio whole-genome sequencing data doubles the yield in [...]

AUTISM IS GENETIC – AUTISM IS TREATABLE – THESE STATEMENTS ARE NOT IN CONFLICT

Summary of an article by Dr. Richard G. Boles entitled: Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half. The full study can be accessed [here). 1/24/24 In a groundbreaking research study published on January 18, 2024, Dr. [...]

Whole exome/genome sequencing in cyclic vomiting syndrome.

Cyclic vomiting syndrome (CVS) is a condition manifested as ongoing intermittent episodes of nausea and vomiting. Episodes can occur in a regular (cyclical) fashion, be triggered by stresses, and/or apparently develop at random, but are similar to each other (stereotypical) in each suffere

Whole Genome Sequencing in 18 patients with Chronic Fatigue

By: Richard G. Boles, M.D. - Dec. 15, 2022 Chronic fatigue is often of unknown cause and is a major factor in suffering and disability

FocusNeeds®: A New Approach for ADHD

By Dr. Richard G. Boles - 9/27/2022. Basically, ADHD is the result of inadequate executive function in the prefrontal cortex. The condition occurs when executive function is insufficient to focus the mind during non-preferred tasks (inattention), and to regulate behavior when challenged by emotions (impulsivity, hyperactivity).

Omega-3 Fatty Acids Demonstrate Benefits in Autism

By: Dr. Richard G. Boles; You may have heard about omega-3 fatty acids (abbreviated omega-3s and pronounced “omega threes”). Omega-3s are among the fatty acids that are essential for life, yet humans cannot make them.

Mitochondrial Dysfunction in Autism Spectrum Disorder

By: Richard Frye, MD, Phd;This is a summary of the article published on October 2020 in connection with the journal Seminars in Pediatric Neurology. The entire article can be found here: https://pubmed.ncbi.nlm.nih.gov/32892956/

A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder

This week, an editorial was published in the Journal of Personalized Medicine, entitled: A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder. This editorial briefly discusses the 21 papers published as part of a Special Edition.

A SECOND CVS CASE STUDY BY DR. RICHARD G BOLES 1/18/2022

Mollie presented with episodes starting at age 1.5 years. Episodes occurred every 6-8 weeks, lasted about 2 days each, and included vomiting up to every 10 minutes, nausea, discomfort with light and sound, extreme lethargy, weakness (whole body), drooling, and thirst.

CYCLIC VOMITING CASE STUDY BY DR. RICHARD BOLES

Dec. 17, 2021;Lauren was evaluated at the age of 6 years with episodes of nausea, abdominal pain, swelling, hives, tiredness, headache, dizziness, and vertigo (spinning sensation). These episodes started in infancy, occurred monthly, lasted four to five days in duration, and were triggered by heat, over-exercise, viral infections, [...]

Western Medicine versus Eastern Medicine – Which approach works best?

By: Richard G. Boles, M.D.; 7/22/21 The center of Western (allopathic) Medicine is to identify the diagnosis, using reductionist techniques to identify the single cause, and based upon that to direct therapy. In contrast, Eastern Medicine believes that there is not a single cause, and that disease relates [...]

CYCLIC VOMITING SYNDROME AND THE MITO COCKTAIL

By: Dr. Richard G. Boles; 4/20/2021 Cyclic vomiting syndrome (CVS) is a functional disorder defined by well-defined episodes of nausea, vomiting, and lethargy (tiredness).

CYCLIC VOMITING SYNDROME EXPLAINED

By: Richard G. Boles, M.D.; March 1, 2021; Like most diagnoses, CVS is defined based on signs and symptoms, not on any underlying cause. People with CVS have episodes of nausea and vomiting.

AUTISM & GENETICS

By: Dr. Richard G. Boles; Autism is, by and large, a genetic condition resulting from variants in a very large number of genes. In general, however, environmental factors often act to trigger the development of disease, while genetics determines the predisposed population at risk.

The Temple Grandin Genome

The Temple Grandin Genome: Comprehensive Analysis in a Scientist with High-Functioning Autism By: Richard G. Boles, M.D. – Jan 7, 2021 As a physician and medical researcher with an interest in autism, of course I have attended lectures given by Dr. Temple Grandin, as well as read many [...]

Why I Created EnergyNeeds®

By Richard G. Boles, M.D. November 19, 2020 Nutritional therapy for mitochondrial dysfunction can make a powerful difference in people with functional (e.g. chronic fatigue, pain, nausea, dizziness), neuro-developmental (e.g. autism, ADHD), and neuropsychiatric (e.g. anxiety, depression) conditions.

STAYING CALM WITH CALMNEEDS®

By: Richard G. Boles, MD CalmNeeds® is a nutritional intervention designed to address behavioral over-activity, which is generally treated by medications for individuals with anxiety, ADHD, mood swings, and other neuro-developmental disorders.

THE GUT, GI AND AUTISM

By: James Neuenschwander, M.D. Gut Abnormalities have been identified as a major co-morbidity to autism spectrum disorder and other neuro-developmental disorders.

A genetic polymorphism associated with mitochondrial energy metabolism increases risk of fibromyalgia

Thus, fibromyalgia is yet another functional disorder that is associated with mtDNA, and therefore energy metabolism/mitochondrial dysfunction plays a role in what causes this condition.

Treatment of Cyclic Vomiting Syndrome (CVS), including supplements and medications, as informed by the latest in genetic testing

By: Richard G. Boles, M.D Cyclic Vomiting Syndrome (CVS) is defined by similar distinct episodes of nausea and vomiting, with reduced or absent manifestations between episodes.

Mitochondria and Immunity – The Critical Link You Must Know About.

By: Pejman Katiraei, DO (Dr. K)Your child (like Ronny) may have a subtle, yet significant, problem with her ability to produce energy, and this energy production error if often the root cause of all other imbalances and problems, including the ones in the gut. Energy is life, and [...]

THE RESTORATION MODEL

By: Dr. Jean-Ronel Corbier The Restoration Model is based on the concept that a return to optimal health is possible. There must be some deviation from normal for illness to occur. This deviation can occur at any time (even very early on e.g. before birth, or during the [...]

NUTRITION IN AUTISM AS INFORMED BY THE LATEST SCIENCE (ABSTRACT)

BY: DR. RICHARD BOLES; PUBLISHED 5/6/2020 Recent scientific advances have determined that there are multiple biological pathways that can predispose an individual toward Autism Spectrum Disorder, with combinations of variants leading to pathway abnormalities unique to each individual.

NEURO-INFLAMMATION IN AUTISM SPECTRUM DISORDERS

By: Dr. Michael Elice; published 4/24/2020 Neuroinflammation is inflammation of the nervous tissue initiated by a variety of triggers including infection, traumatic brain injury, toxic exposure and autoimmunity.

Mitochondrial Dysfunction & Dietary Supplementation in ADHD & Anxiety

By: Dr. Richard Boles; 4/13/2020 Attention deficit disorder, both with (ADHD) and without (ADD) hyperactivity, (herein abbreviated as AD/HD) is the most frequent of all neurodevelopmental disorders (NDDs), being present in 5-7% of children and 2.5-5% of adults.

Anxiety Is Not Anxiety: When Mito Errors Cause the Nervous System to Falter

By: Dr. Pejman Katiraei; (3/23/2020) Energy is the currency of life. Without it, we perish. Energy is needed for every organ and system within our body to function, and these systems include: the brain, muscles, liver, adrenal glands, gastrointestinal tract, kidneys, etc. There is no system within the [...]

Coronavirus COVID-19 Update (March 16, 2020). Observations from Richard Boles, MD*:

People all over the world are rightfully concerned about the novel coronavirus pandemic, particularly in regards to groups of people thought to be vulnerable, such as the elderly and people with “underlying medical conditions”.

A Summary of:“State of the Art Genetic Testing for Patients with Autism: A Practical Guide for Clinicians”

Summary By: Nicholas Gorra; published on 3/10/2020. Current genetic testing provides a precise diagnosis in about one-half of cases with autism. Beyond diagnosis, genetic testing can oftentimes help elucidate potentially-treatable risk factors that predispose the individual patient to develop disease, and lead to improved outcomes in as many [...]

THE GUT

By Emrys Tetu; Published on 3/5/2020 The more we learn, the more we realize that your GUT's happiness is key to your full-body wellness. And so a happy, healthy winter (mood included!) gets a boost from a happy, healthy microbiome.

GENETIC TESTING IN NEURODEVELOPMENTAL DISORDERS

By: Dr. Richard Boles; Published on 2/24/2020 The last few years have demonstrated continued rapid improvements in terms of the technology enabling genetic testing, the number and types of genetic tests that are clinically and commercially-available, and the knowledge base used to interpret test results.

Who Needs a Good Night’s Sleep Anyway?

By: Nicholas Gorra; Published 2/17/2020 Researchers at the University College London found a clear clinical and statistically significant link between bedtimes and behavior. Irregular bedtimes affected children's behavior by disrupting circadian rhythms (body clock), leading to sleep deprivation that affects the developing brain.

EPILEPSY IN AUTISM SPECTRUM DISORDER

By: Dr. Richard Frye; Published on 2/10/2020 Epilepsy is one of the most common neurological conditions that effect children with ASD and may affect up to one-third or more of individuals with ASD.

ULTRA-PROCESSED FOODS: CONVENIENT BUT AT WHAT PRICE?

By: Nicholas Gorra; Published 1/29/2020 What are ultra-processed foods? They aren’t just snack foods like potato chips, fizzy drinks, store bought fruit pies, and the like; they also include items such as frozen dinners, deli meats, instant noodles and sweets.

The Scoop on Coenzyme Q10, as well as, What Is NOT in the Scoop?

By Richard G. Boles, M.D. Updated January 2020. Overview: Coenzyme Q10 (CoQ10) is an essential electron carrier in the respiratory chain, where almost all of the energy for the body is produced. It also functions as an antioxidant, which protects the body from damage caused by harmful molecules.

THE IMPORTANCE OF BEING CALM (AND 6 GOOD WAYS TO GET THERE)

By Nick Gorra, Updated January 2020 Overview: We’ve all seen the banner “Keep Calm and Carry on”. There are lots of articles about the importance of being calm and how to get there. But the key question really is: Why do we need to be calm?

CHECK OUT OUR BUMPER MAGNET CONTEST.

Every buyer of a NeuroNeeds product for the months of January- April 2020 will receive a bumper magnet. Just affix this bumper magnet to your car, take a photo and post on social media using #neuroneeds2020; PLEASE MAKE SURE YOUR PROFILE IS PUBLIC SO WE CAN SEE YOUR [...]

COME MEET WITH US: NEURONEEDS’ CONFERENCES CALENDAR:

January 2020 Hawaii Doc Talks January 16 @ 8:00 am – January 19 @ 5:00 pmKahala Hotel & Resort, 5000 Kahala Avenue HI 96816 United States + Google MapFind out more » TACA Hawaii – Mito Medicine January 19 @ 2:30 pm – 4:30 pmKapolei Heritage Center, 91-1250 Kinoiki StreetKapolei, HI 96707 + Google MapFind out more » Complex Health Conditions [...]

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