Alpha-ketoglutarate, malate, and citrate are organic acids that serve as intermediates in the citric acid (Krebs) cycle. This metabolic cycle releases stored energy through the oxidation of carbohydrates, fats, and proteins, and is fundamental to life. These intermediates can be synthesized in the body, and are not required in the diet. The role of citric acid cycle intermediates in the treatment of mitochondrial dysfunction has not been studied. In Dr. Boles’ experience, many people with mitochondrial dysfunction have abnormal levels of Krebs cycle intermediates, including alpha-ketoglutarate, malate, and/or citrate.
Alpha-ketoglutarate, malate, and citrate: Citric acid cycle intermediates
Alpha-ketoglutarate and citrate in ActivNeeds
These citric acid cycle intermediates are added in order to support mitochondrial energy metabolism. In addition to alpha-ketoglutarate, these intermediates are provided in the forms of malic acid, magnesium citrate, and potassium citrate. Side effects are unexpected.
What Is It?
Alpha-ketoglutarate, malate, and citrate are organic acids that serve as intermediates in the citric acid cycle.
What Does It Do?
The citric acid cycle, also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle, is a series of chemical reactions used to release stored energy through the oxidation of carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of NADH and ATP. This cycle is fundamental to all aerobic (oxygen – requiring) life, including humans.
What Does Deficiency Appear as?
Alpha – ketoglutarate, malate, and citrate can be synthesized in the body by the citric acid cycle, and are not required in the diet.
Deficiency is unknown.
What About Its Use in Various Situations
Alpha-ketoglutarate is sometimes used to boost athletic performance and to help heal wounds. In addition, alpha-ketoglutarate can reduce levels of ammonia (and excess nitrogen) formed in the brain, muscles and kidneys. Malate/malic acid, malic acidis sometimes recommended for fibromyalgia and fatigue. Citrate is frequently provided as part of mineral supplements. Citrate is sometimes used to prevent kidney stones and to alkalize the blood or urine in various conditions
What About Common and Important Side Effects?
Side effects are rare at usual doses used in supplementation
Is There Any Laboratory Testing?
Urine organic acid testing can quantify these citric acid intermediates, but this is not likely to be of clinical utility other than in screening for metabolic/mitochondrial disorder
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